The Weiss lab has developed a mouse models for tumors of the nervous system, including genetically engineered mouse models for glioma, medulloblastoma and neuroblastoma, as well as more novel models for these tumors based on differentiation and transformation of human iPS cells. We have established these as platforms for biology, genetics, and developmental therapeutics, having published preclinical trials using both chemotherapeutic and targeted agents, in parallel with analyses of primary human tumors. Our focus: 1). EGFR/PI3K/mTOR biology, 2). Chemical genetic approaches to kinase function, and 3). Developing inhibitors of kinases that stabilize MYC family proteins, as a MYC-directed therapy. Dr. Weiss co-leads that Pediatric Malignancies Program within UCSF’s Helen Diller Family Comprehensive Cancer Center, is a senior editor of Cancer Research, and is associate editor of Molecular and Cellular Biology, Scientific Reports, and Neuro-Oncology. He received a B.S. from Tufts, MD-PhD from Stanford, clinical training in pediatrics and in neurology at Boston Children’s Hospital and UCSF, and was a postdoc with Mike Bishop.